Table 2.
Genes associated with non-syndromic congenital heart diseases.
| Condition | Gene | Chromosome location |
|---|---|---|
| Septal defects; abnormal conduction; tetralogy of Fallot; left heart hypoplasia | NKX2-5 | 5q35.1 |
| Tetralogy of Fallot; double outlet of right ventricle; ventricular septal defects | NKX2-6 | 8p21.2 |
| Septal defects; double outlet of the right ventricle | TBX20 | 7p14.2 |
| Septal defects; double outlet of the right ventricle; tetralogy of Fallot | GATA4 | 8p23.1 |
| Tetralogy of Fallot; familial atrial fibrillation | GATA5 | 20q13.33 |
| Outflow tract defects | GATA6 | 18q11.2 |
| Heterotaxy | ZIC3 | Xq26.3 |
| Atrial isomerism, D-transposition of great arteries | PITX2 | 4q25 |
| Familial atrial septal defect | MYH6 | 14q11.2 |
| Tetralogy of Fallot | JAG1 | 20p12.2 |
| Left heart hypoplasia | NOTCH2 | 1p12 |