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. 2021 Jun 24;30(21):1985–1995. doi: 10.1093/hmg/ddab167

Figure 5 .

Figure 5

(A, B) GO analysis on pathways identified from up-regulated genes using RNA-seq on WT (284 genes) and Tet2−/− (879 genes) AR mice, respectively. (C) GO analysis results of Tet2−/− AR mice up-regulated genes from RNA-seq that showed a dosage effect with Tet2 (Tet2−/− > Tet2+/− > WT, 497 genes) suggest the significant involvement of the antigen processing and presentation pathway. (D) Of the 91 genes in the antigen processing and presentation pathway, 27 genes were captured in Tet2-KO AR mice [first pathway in (B)], with 19 of these genes showing a dosage effect with the loss of the Tet2 gene [first pathway in (C)]. (E) Heatmap of log 2 folds change of genes that involved in the first pathway of (B) and (C). *MHC molecules but do not belong to the antigen processing pathway. (F) IGV view of 5hmC dynamic changes in some MHC and linked genes. Green arrow, AR-gain-DhMRs loci (P-value > 0.05).