Table 4.
Influence of maternal genetics on birth weight, considering obstetric outcomes, clinical and anthropometric characteristics.
| Characteristics | Birth weight |
|||
|---|---|---|---|---|
| Unadjusteda | p-value | Adjusteda | p-value | |
| Β coefficient (95% CI) | Β coefficient (95% CI) | |||
| GCK rs1799884 | ||||
| Mm | -7.00 (-146.68; 32.67) | 0.92 | 34.79 (-96.58; 166.17) | 0.62 |
| mm | -191.31 (-551.61; 168.98) | 0.29 | -335.25 (-669.39; -1.17) | 0.04 |
| TCF7L2 rs7903146 | ||||
| Mm | 55.21 (-78.41; 188.85) | 0.41 | 48.83 (-73.89;171.57) | 0.43 |
| mm | 15.76 (-228.48; 260.02) | 0.89 | 21.53 (-205.47; 248.55) | 0.85 |
| LEPR rs1137101 | ||||
| Mm | -81.39 (-229.07; 66.28) | 0.27 | -63.26 (-199.97; 73.44) | 0.36 |
| mm | -133.22 (-307.65; 41.20) | 0.13 | -88.30 (-248.51; 71.89) | 0.27 |
| Vitamin D (per nmol/L) | 3.33 (1.29; 5.36) | < 0.01 | 3.34 (1.36; 5.31) | < 0.01 |
| Maternal pre-pregnancy BMI (per kg/m²) | 27.37 (14.50; 40.25) | < 0.01 | 25.06 (12.63; 37.48) | < 0.01 |
| Gestational age (per week) | 68.11 (36.36; 99.86) | < 0.01 | 61.22 (29.91; 92.52) | < 0.01 |
| Sex of the baby (female) | -173.60 (-298.16; -49.04) | < 0.01 | -221.60 (-340.57; -102.62) | < 0.01 |
| Planned pregnancy (yes) | -31.66 (-162.49; 99.15) | 0.63 | 42.95 (-81.08; 166.99) | 0.49 |
| Race (black/brown) | 66.52 (-101.84; 234.89) | 0.43 | 77.81 (-83.89; 239.53) | 0.34 |
| Education (< 12 years) | 29.01 (-110.80; 168.84) | 0.68 | -58.55 (-189.95; 72.84) | 0.38 |
Mm, heterozygous; mm, homozygous for the minor allele; MM, homozygous for the major allele.
a
Simple and multiple linear regression analysis – Beta coefficient with 95% confidence interval: values showed represent increase or decrease (in grams) in birth weight according to the genotype of each polymorphism with or without 1-unit of co-conditioning. MM was used as reference group.