Table 1.
Demographic and clinical characteristics of survivors and non-survivors.
| Characteristic | Survivors (n = 488) | Non-survivors (n = 28) | p-value |
|---|---|---|---|
| Male, No. (%) | 311 (63.7) | 16 (57.1) | 0.482 |
| Age, median (IQR), Months Site of infection, No. (%) |
8 (2–36) | 12 (3–36) | 0.479 |
| Respiratory system | 280 (57.4) | 11 (39.3) | |
| Nervous system | 72 (14.8) | 6 (21.4) | |
| Digestive system | 43 (8.8) | 2 (7.1) | |
| Blood | 6 (1.2) | 0 | |
| Urinary tract | 13 (2.6) | 0 | |
| Other | 74 (15.2) | 9 (32.1) | |
| Sepsis classification | ≤0.001 | ||
| Sepsis, No. (%) | 238 (49) | 0 (0) | |
| Severe sepsis, No. (%) | 242 (50) | 20 (71) | |
| Septic shock No. (%) | 8 (1) | 8 (29) | |
| Required mechanical Ventilation, No. (%) |
69 (14.1) | 22 (78.6) | ≤0.001 |
| Required vasoactive Infusion on day 1, No. (%) Auxiliary examination |
8 (1.6) | 6 (21.4) | ≤0.001 |
| Glasgow scale [score, median (IQR)] | 13 (11–13) | 7 (4-9) | ≤0.001 |
| PaO2 [mmHg, median (IQR)] | 97 (80–115) | 104 (62–136) | 0.887 |
| PaCO2 [mmHg, median (IQR)] | 30.7 (25.6–35.0) | 27.2 (22.6–38.58) | 0.536 |
| Lactic acid concentration [umol/L, median (IQR)] | 1.2 (0.8–2.0) | 2.9 (1.1–10.3) | ≤0.001 |
| Creatinine values [umol/L, median (IQR)] | 22.6 (17.0–31.0) | 30.0 (16.5–55.3) | 0.051 |
| Blood urea nitrogen [mmol/L, median (IQR)] | 3.2 (2.4–4.3) | 4.4 (2.8–6.7) | 0.006 |
| Total bilirubin concentration [umol/L, median (IQR)] | 6.4 (4.6–10.3) | 8.7 (5.9, 19) | 0.04 |
| Fibrinogen concentration [g/L, median (IQR)] | 2.7 (2.0–3.5) | 1.8 (1.2–3.0) | 0.001 |
| White blood cell values [*109/L, median (IQR)] | 13.4 (9.0, 19.0) | 15.4 (9.5, 20.6) | 0.407 |
| Platelet values [*109/L, median (IQR)] | 323 (240, 427) | 292 (211, 388) | 0.132 |
| Scores on day 1 [score, median (IQR)] | |||
| PELOD-2 | 0 (0–2) | 6.5 (4–8) | ≤0.001 |
| qPELOD-2 | 0 (0–1) | 1 (1–2) | ≤0.001 |
| pSOFA | 3 (2–4) | 7.5 (6–11) | ≤0.001 |
| P-MODS | 1 (1–2) | 3 (2–6) | ≤0.001 |
| Outcomes, median (IQR) Duration of ventilatory support, d PICU LOS ≥ 72 h (%) PICU LOS, days |
0 (0–0) 251 (51.4) 1 (1–8) |
2 (1–5) 16 (57.1) 3 (2–6) |
≤0.001 0.698 0.686 |
| Hospital LOS, days | 9 (6–15) | 3 (2–6) | ≤0.001 |
PICU, pediatric intensive care unit; IQR, interquartile range; LOS, length of stay; PELOD-2, Pediatric Logistic Organ Dysfunction Score-2; qPELOD-2, quick Pediatric Logistic Organ Dysfunction Score-2; pSOFA, pediatric Sequential Organ Failure Assessment; P-MODS, Pediatric Multiple Organ Dysfunction Score.