Table 1.

Screening laboratory tests for the non-immunology specialist to detect patients with possible primary immunodeficiency.

Possible PID	Screening tests
Antibody-mediated immunity (AMI)	• Complete blood count • Serum IgG, IgA, IgM • Antibody titers for protein and polysaccharide vaccines
Cell-mediated immunity (CMI)	• Complete blood count • Lymphocytes: CD3, CD4, and CD8; CD19; CD16/56 • Chest X-ray
Complement (C)	• C4 (if there is angioedema without urticaria) • CH50
Phagocytosis (P)	• Neutrophile count
Neutropenia	• DHR/oxidative burst
Neutrophil function Autoimmunity	• ANA, CRP
Inborn immunity (II)	• Specialized tests (see an immunologist)

The screening tests should be part of any initial immunological assessment. Only the abbreviations in parentheses will be listed as suggested screening tests in all subsequent tables. The HIV test should be a routine test to exclude AIDS. Abbreviations: ANA, antinuclear antibodies; CBC, complete blood count; DHR, dihydro-rhodamine oxidation test; CRP, C-reactive protein.

Adapted from de Costa-Carvalho et al.⁵