Table 2.

Univariate and Multivariable Analysis of Post-Hepatectomy Liver Failure Factors

Characteristics	Univariable Logistic Regression		Multvariable Logistic Regression
	OR (95% CI)	P value	OR (95% CI)	P value
(Intercept)			6.558(0.021–14.153)	0.618
Age, years	1.017(0.984–1.052)	0.320
Gender, (Female vs male)	0.606(0.247–1.643)	0.294
Hypertension, (Yes vs No)	0.181(0.01–0.901)	0.099
Causes of cirrhosis, (HBV vs HCV vs Others)	1.6(0.82–2.933)	0.138
Cirrhosis, (Yes vs No)	7.622(1.556–137.786)	0.049
Portal hypertension, (Yes vs No)	6.774(3.322–14.172)	<0.001	3.344(1.762–6.398)	<0.001
Extent of resection, (Major vs Minor)	2.243(1.002–4.832)	0.043	3.528(1.607–7.715)	0.002
Blood loss, (≥400 vs <400 mL)	1.903(0.954–3.771)	0.065
Transfution, (Yes vs No)	2.067(0.928–4.423)	0.066
ALT, U/L	1.006(1.001–1.011)	0.022	1.003(1.002–1.011)	0.013
AST, U/L	1.003(0.999–1.007)	0.195
Albumin, g/L	0.846(0.776–0.917)	<0.001
Total bilirubin, μmol/L	1.123(1.067–1.188)	<0.001	1.036(1.031–1.184)	0.005
Creatinine, μmol/L	0.982(0.958–1.005)	0.138
PT, s	2.163(1.582–3.032)	<0.001
RBC, 1012/L	0.387(0.202–0.719)	0.003
Platelet, 109/L	0.987(0.98–0.993)	<0.001	0.994(0.988–0.999)	0.028
AFP, (≥400 vs <400 ng/mL)	1.186(0.577–2.372)	0.634
Child-Pugh class, (class-B vs class-A)	4.133(1.651–10.611)	0.002
MELD score	1.331(1.162–1.538)	<0.001
ALBI score	11.469(4.505–32.143)	<0.001	1.678(0.762–8.022)	0.156
APRI	1.32(1.082–1.674)	0.015
FIB-4 score	1.167(1.074–1.28)	0.001

Abbreviations: PHLF, post-hepatectomy liver failure, ALT, alanine transaminase; AST, aspartate transaminase; PT, prothrombin time; INR, international normalized ratio; RBC, red blood cell; AFP, a-fetoprotein; MELD, Model For End-Stage Liver Disease; ALBI, Albumin-bilirubin; APRI, AST-to-platelet ratio index; FIB-4, Fibrosis 4.