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. Author manuscript; available in PMC: 2022 Aug 31.
Published in final edited form as: J Intern Med. 2020 Nov 19;288(6):651–660. doi: 10.1111/joim.13191

Figure 3. Identification of antigen-specificity can inform vaccination strategies.

Figure 3.

Proteome-wide definition of T cell antigens and epitopes following BCG vaccination (blue) and Mtb infection (red). If antigens dominantly recognized following BCG vaccination only are removed vaccine efficacy may be improved. Antigens that are recognized following BCG vaccination and in Mtb infection are candidates for prime-boost regimens. Antigens only recognized in Mtb infection can be used as diagnostics (for example IGRA antigens) or are vaccine candidates to induce immune responses beyond what BCG triggers to improve efficacy. All separate categories can be used as molecular tools to measure immune responses.