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. 2022 Aug 17;13:964370. doi: 10.3389/fphar.2022.964370

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Copyright © 2022 Wang, Liu, Ren, Suo, Zou, Zhang, Yu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SKI controlled blood pressure and inhibited RAS activation in CKD rats. (A) Serum creatinine levels in adenine-induced rats treated with three doses of SKI (10, 20, 30 ml/kg/d). (B) SBP and DBP in adenine-induced rats treated with SKI. (C) Protein expression of intrarenal RAS components, including ACE and AT₁R, in adenine-induced rats treated with SKI. (D) Quantitative analysis of the protein expression of intrarenal RAS components, including ACE and AT₁R, in adenine-induced rats treated with SKI. (E) Immunohistochemical analysis of intrarenal ACE and AT₁R in adenine-induced rats treated with SKI. Scale bar, 40 μm **p < 0.01 compared with CTL rats; ^# p < 0.05, ^## p < 0.01 compared with CKD rats. Abbreviations: DBP, diastolic blood pressure; SBP, systolic blood pressure; SKI, shenkang injection.