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. 2022 Aug 17;13:964370. doi: 10.3389/fphar.2022.964370

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Copyright © 2022 Wang, Liu, Ren, Suo, Zou, Zhang, Yu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SKI suppressed Wnt1/β-catenin signalling in CKD rats. (A) Immunohistochemical analysis of intrarenal Wnt1 expression in the different groups. (B) Immunohistochemical analysis of intrarenal β-catenin expression in the different groups. (C) Protein expression levels of intrarenal Wnt1, active β-catenin and β-catenin in the different groups. (D) Quantitative analysis of the protein expression of intrarenal Wnt1, active β-catenin and β-catenin in the different groups. Scale bar, 40 μm **p < 0.01 compared with CTL rats; ^# p < 0.05, ^## p < 0.01 compared with CKD rats. Abbreviations: CHR, chrysophanol; EMO, emodin; RHE, rhein.