TABLE 3.
PA metabolism gene sets
| Pathway | Description | Genes |
|---|---|---|
| Synthesis | Polyamine biosynthesis. | ODC1, SRM, SMS, AMD1 |
| Catabolism | Polyamine catabolism. | SAT1, PAOX, SMOX |
| Regulatory | Regulation of biosynthesis and transport. | OAZ1, OAZ2, OAZ3 |
| Transport | Putative polyamine transporters. | ATP13A2, GPC1, SLC3A2, SLC7A2, SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10, SLC7A11, SLC12A8, SLC18B1, SLC22A1, SLC22A2, SLC22A3, SLC22A16, SLC47A1 |
| Putrescine | Putrescine biogenesis. | PAOX, SAT1, ODC1 |
| Spermidine | Spermidine biogenesis. | PAOX, SAT1, SRM, SMOX, AMD1 |
| Hypusine | Hypusine biogenesis. | DHPS, DOHH |
| Combined | Empirically defined by negative correlation with CTLa ssGSEA score across cancers. | ODC1, SMS, SMOX, AMD1, ALDH18A1, PRODH, OAT, OAZ2, GPC1, SLC3A2, SLC7A1, SLC7A2 |
aCytotoxic lymphocyte gene set as defined in Bindea and colleagues.