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. 2022 Aug 31;13(2):378–385. doi: 10.1007/s13346-022-01232-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Representative therapeutic gold nanoconstructs in clinical trials. A Schematic representation of CYT-6091. B Comparison of ex vivo organ accumulation of non-PEGylated (TNF-AuNP) and PEGylated CYT-6091. Adapted with permission of ref 22. Copyright 2012 CytImmune. C Schematic representation of NU-0129. D Au elemental map of glioblastoma tumor sample and matching Ki67 staining after NU-0129 treatment. Arrows highlight gold accumulation regions within perivascular Ki67-positive cancerous cells. E Silver staining of glioblastoma tumors before and after NU-0129 treatment. Adapted with permission of ref 36. Copyright 2020 American Association for the Advancement of Science. F Schematic representation of AuroShell. Adapted with permission of ref 38. Copyright 2015 Elsevier. G Pre- and post-treatment images of patient with focal prostate cancer treated with AuroShell and photoablation. Imaging techniques: t2-weighted magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance (DCE-MRI) imaging. Arrows highlight tumoral region. H Picture of lasers introducers in thermocouple through transperineal grid. Adapted with permission of ref 40. Copyright 2019 National Academy of Science