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. Author manuscript; available in PMC: 2022 Aug 31.
Published in final edited form as: Nat Aging. 2022 Aug 11;2(8):714–725. doi: 10.1038/s43587-022-00261-5

Extended Data Fig. 5 |. Comparison of mutational signatures identified in this and other studies.

Extended Data Fig. 5 |

(Left panel) De novo mutational signatures identified from single human cardiomyocytes in this study. (Middle panel) Previously published signatures identified from single human neurons (Lodato et al.). (Right panel) Recently published signatures thought to represent artifacts of single-cell whole genome amplification, SBS scE and scF, from a study of cultured cells (Petljak et al.). Signature D/N4 was present only in cardiomyocytes but not in neurons. Signature B/N1 identified in cardiomyocytes and neurons resembles the artifact signature SBS scF, thus it was excluded for further mutational burden and signature analyses in this study.