TABLE 3.

Suggested Features for PROMS Assessing Symptoms, Side Effects, and HRQoL Related to PLD Treatment

Feature	Need to Have	Nice to Have
Validation	Validated	—
Symptoms	Assesses PLD-specific symptoms (yes/no)	Includes threshold to select patients for treatment
HRQoL	Provides an overall indication of HRQoL Can detect clinically relevant changes in HRQoL	Includes specific HRQoL subdomains (ie, emotional health, health perception)
Complications and side effects	Includes most frequent complications and side-effects associated with the treatment	Includes options to report unexpected side effects or complications
Time needed	≤30 minutes	≤15 minutes
Language	Language use understandable for the entire population	Available in multiple languages to enable cross-country comparability
Frequency of administration (medical therapy)	At baseline and after stopping the treatment	During treatment with an appropriate interval depending on the therapy During follow-up period after stop treatment Treatment-specific effects on symptom burden, HRQoL and complications should be taken into account when administering the PROM during follow-up
Frequency of administration (radiologic and surgical)	Baseline and at the end of follow-up	Treatment-specific effects on symptom burden, HRQoL and complications should be taken into account when administering the PROM during follow-up