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. Author manuscript; available in PMC: 2022 Aug 31.
Published in final edited form as: Adv Genet. 2016 Jan 22;93:191–236. doi: 10.1016/bs.adgen.2015.12.003

Fig. 6. Chaperone-catalyzed filament cleavage generates new prion seeds.

Fig. 6.

Hsp104, in collaboration with Hsp70 and Hsp40, extract a prion protein monomer from the middle of a filament, breaking the filament into two filaments, each of which can continue to grow and propagate the prion. Adapted from reference (Masison et al. 2009).