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. Author manuscript; available in PMC: 2022 Aug 31.
Published in final edited form as: Adv Genet. 2016 Jan 22;93:191–236. doi: 10.1016/bs.adgen.2015.12.003

Fig. 7. Btn2p collects protein aggregates, thereby curing the [URE3] prion.

Fig. 7.

Btn2p, acting with Hsp42, gathers prion filaments (and other aggregates) to one place in the cell. Following cell division, one of the daughter cells is prion-free. Low seed number [URE3] prions are cured by normal levels of Btn2p, while higher propagon number [URE3]s are only cured on overproduction of Btn2p. Modified from Wickner et al., 2015.