Table 1.

Prions of Yeast, Fungi and Mammals

Prion	Prion protein	Prion phenotype	Protein function	Reference
TSE	PrP	transmissible spongiform encephalopathy	GPI-anchored cell surface glycoprotein, function not clear	(Prusiner 2004)
[URE3]	Ure2p	derepressed nitrogen catabolism genes	repression of nitrogen catabolism gene transcription (e.g. DAL5)	(Wickner 1994)
[PSI+]	Sup35p	readthru of translation termination codons	subunit of translation termination factor	(Wickner 1994)
[PIN+]	Rnq1p	rare priming of formation of other prions	non-essential; function unknown	(Derkatch et al. 2001)
[SWI+]	Swi1p	deficient in utilizing non-fermentable carbon sources	chromatin remodeling	(Du et al. 2008)
[OCT+]	Cyc8p	slow growing, with defects in mating and sporulation	subunit (with Tup1p) of transcription repressor	(Patel et al. 2009)
[ISP+]	Sfp1p	antisuppressor, overproduces Sup35p	transcription factor for ribosome proteins	(Rogoza et al. 2010)
[MOT3+]	Mot3p	filamentous growth on low nitrogen	transcription factor for hypoxic, hyperosmotic stress	(Alberti et al. 2009)
[MOD5+]	Mod5p	slow growth, fluconazole-resistance	tRNA isopentenyltransferase	(Suzuki et al. 2012)
[BETA]	Prb1p	activation of Prb1p precursor by active Prb1p	Vacuolar protease B	(Roberts and Wickner 2003)
[Het-s]	HET-s	heterokaryon incompatibility in Podospora anserina	heterokaryon incompatibility (no non-prion function known)	(Coustou et al. 1997)