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. 2022 Aug 31;8(35):eabo7958. doi: 10.1126/sciadv.abo7958

Fig. 7. Hypothesis for JAG1-NOTCH4 control of reparative endothelial subsets in atherosclerosis.

Fig. 7.

We hypothesize that LOSS activates JAG1-NOTCH4 signaling, which promotes atherosclerosis by altering the balance of reparative and pathogenic EC subsets.