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(A) Known regulators and cellular functions of Cya. Insights into the function of the membrane domain of Cya, with new functions of the transmembrane (TM) domain suggested by the cryo-EM structure: a stabilizer of the cytosolic domain assembly (B), a receptor for positively charged agents via the Ex1 site at the Cya dimer interface (C), and a receptor of yet unknown ligands via sites Ex2/Cy1/Cy2 (D).
