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. 2022 Sep 1;132(17):e157279. doi: 10.1172/JCI157279

Figure 4. KRT14+ Kera1 cluster expresses low transcripts of identified EMT-related genes.

Figure 4

(A) Violin plot showing expression of KRT14 in the identified 11 clusters obtained through scRNA-Seq analyses. (B) tSNE plot with KRT14+ Kera1 (cluster 5) color-coded purple (left) and expression of KRT14 in the Kera1 cluster (right). (C) Expression level of TP53 in Kera1 derived from human UW skin (left) and chronic WE (right). (P < 0.0001; χ2 test). (D) Expression levels of ADAM17, NOTCH1, SMURF1,and TWIST1 in human UW skin and chronic WE. Scale bar for expression levels: scale 1–3. (P < 0.05, except for TWIST1; χ2 test). (E) Network of Reactome pathways enrichment of the downregulated pathways in Kera1 epithelial cells of chronic WE (CW) compared with human UW skin (adjusted P < 0.001 and at least 8% of the pathway genes found in the DEG). NGF, nerve growth factor; NMD, nonsense-mediated decay; EJC, exon junction complex; SRP, signal recognition particle; SLIT, slit guidance ligand 1; ROBO, roundabout.