Fig. 1.
A. SNAP5114 (GAT-3 antagonist, 20 μM) (dashed lines) caused an increase in decay time of evoked GABA responses in GPe neurons due to activation of iMSNs in both WT and R6/2 mice. B. SNAP5114 bath application caused no significant change in average amplitude in either WT or R6/2 GPe neurons. However, a significant increase in decay time was observed in both groups. Each dot represent one individual cell. C. The percent change of decay time of WT neurons was significantly larger than in R6/2 neurons after application of SNAP5114.