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. 2022 Aug 24;2022:9729018. doi: 10.1155/2022/9729018

Figure 3.

Figure 3

An influence of MMP-2 siRNA on heart function: heart rate (a). RPP calculated as the product of the heart rate and left ventricular developed pressure (heart rate x left ventricular developed pressure/1000) (b). Recovery of heart mechanical function (difference between RPP at 25th and 77th min of perfusion expressed as a percentage of RPP recovery) (c). Correlation between heart mechanical function recovery, heart rate and MMP-2 activity (d); MMP-9 activity (e) in heart homogenates; straight line: standard curve; dotted line: 95% confidence band. Aero: aerobic control group; bpm: beats per minute; HR: heart rate; I/R: ischemia-reperfusion group; MMP-2: matrix metalloproteinase 2; MMP-9: matrix metalloproteinase 9; RPP: rate pressure product. Mean ± SEM, nAero = 3; nAero+MMP−2 siRNA = 2; nI/R = 5; nI/R+scrRNA = 5; nI/R+MMP−2 siRNA = 4. ∗p < 0.05 vs. Aero, #p < 0.05 vs. I/R, and $p < 0.05 vs. I/R+scrRNA.