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TIMP-4 level in rat hearts (a). Correlation between TIMP-4 level and MMP-2 (b) and MMP-9 (c) synthesis/activity in rat hearts. Correlation between TIMP-4 level in rat hearts and HR/RPP (d). Straight line: standard curve; dotted line: 95% confidence band. Aero: aerobic control group; I/R: ischemia/reperfusion; MMP-2: matrix metalloproteinase 2; TIMP-4: endogenous tissue inhibitor of matrix metalloproteinase 4.
