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. 2022 Jul 18;2022:5623555. doi: 10.1155/2022/5623555

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Copyright © 2022 Hongwei Shi et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

SchB inhibited ferroptosis and oxidative stress on hepatocytes cultured with THP. Effects of different concentrations of THP on cell viability (a). Effects of different concentrations of SchB with 5 μM THP on cell viability (b). The levels of ROS increased, which decreased with Fer-1 or SchB treatment in THP hepatocytes (c). The relative fluorescence intensity provides more evidence (d). The levels of NRF2, SOD2, GPX4, and Bcl-2/Bax decreased in THP hepatocytes (e). In addition, the expression of NOX2/4 and cleaved caspase-3 was slightly increased (e). However, SchB treatment eliminated these adverse reactions (e). Semiquantitative analysis provides more evidence (f). Values are expressed as mean ± SEM. ^∗P < 0.05 vs. CON and ^#P < 0.05 and ^&P < 0.05 vs. THP. CON: control; SchB: schisandrin B; THP: pirarubicin; Fer-1: ferrostatin-1; NRF2: nuclear factor erythroid 2 like 2; NOX2/4: NADPH oxidase 2/4; SOD2: superoxide disproportionation 2; GPX4: glutathione peroxidase 4; Bcl-2: B-cell lymphoma-2; Bax: Bcl-2-associated X.