Table 2.
Weight change pattern and serum soluble klotho levels (pg/ml) in men and women aged 40–79 years.
| Never obese (ref) | Obese to nonobese | Nonobese to obese | Always obese | |
|---|---|---|---|---|
| Men | ||||
| BMI 10 years prior to baseline BMI | ||||
| Model 1 | 765.0 | 742.4 | 757.4 | 780.5 |
| Model 2 | 765.0 | 742.4 | 765.0 | 780.5 |
| Model 3 | 765.0 | 735.0 | 765.0 | 772.7 |
| BMI age 25 years to baseline BMI | ||||
| Model 1 | 765.0 | 749.9 | 765.0 | 796.3 |
| Model 2 | 765.0 | 757.4 | 765.0 | 788.3 |
| Model 3 | 765.0 | 765.0 | 765.0 | 772.7 |
|
| ||||
| Women | ||||
| BMI 10 years prior to baseline BMI | ||||
| Model 1 | 820.5 | 812.4 | 765.0∗ | 788.3∗ |
| Model 2 | 820.5 | 820.5 | 757.4∗ | 780.5∗ |
| Model 3 | 820.5 | 828.8 | 757.4∗ | 780.5∗ |
| BMI age 25 years to baseline BMI | ||||
| Model 1 | 820.5 | 871.3 | 772.7∗ | 796.3 |
| Model 2 | 820.5 | 897.8 | 765.0∗ | 796.3 |
| Model 3 | 820.5 | 888.9 | 765.0∗ | 796.3 |
∗ P < 0.05 compared with the reference category never obese. Model 1: adjusted for age- and gender, model 2: adjusted for model 1 and race/ethnicity, education, smoking, alcohol use, and physical activity, and model 3: adjusted for model 2 and diabetes, eGFR, and 25 (OH)D levels.