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. 2022 Aug 24;2022:1911592. doi: 10.1155/2022/1911592

Figure 4.

Figure 4

circLMTK2 is directly bound to miR-485-5p. (a) The binding sites of miR-485-5p in circLMTK2. (b–d) The miR-485-5p expressions in PC and GEM-resistant PC tissues and cell lines were determined by the qRT-PCR assay. (e) The luciferase reporter assay was used to determine the physical connection between circLMTK2 and miR-485-5p. (f) The success of miR-485-5p inhibition with miR-485-5p inhibitor was confirmed by qRT-PCR analysis. (g) The CCK-8 assay was used to determine cell proliferation. (h–j) Wound healing and transwell assays were carried out to detect cell invasion and migration. (k) The TUNEL assay was used to determine cell apoptosis. ∗∗P < 0.01; ∗∗∗P < 0.001 vs. NC group; ###P < 0.001 vs. sh-circLMTK2 group.