Table 2.
Diagnostic performance of single-photon emission computed tomography, positron emission tomography, and magnetic resonance imaging for the detection of fractional flow reserve-defined significant coronary artery disease
| % (95% CI) | |||
|---|---|---|---|
| SPECT | PET | MRI | |
| Per patient | |||
| Sensitivity | 67 (58–76) | 81 (72–87) | 66 (56–75) |
| Specificity | 61 (48–72) | 65 (53–76) | 62 (49–74) |
| PPV | 74 (68–80) | 80 (74–85) | 75 (68–81) |
| NPV | 53 (45–60) | 66 (57–75) | 51 (43–59) |
| Accuracy | 65 (58–72) | 75 (68–81) | 64 (57–72) |
| AUC | 0.66 (0.58–0.73) | 0.80 (0.73–0.86) | 0.67 (0.59–0.74) |
| Per vessel | |||
| Sensitivity | 60 (52–67) | 73 (66–79) | 44 (35–52) |
| Specificity | 70 (66–75) | 69 (64–73) | 82 (77–86) |
| PPV | 49 (44–54) | 53 (49–58) | 53 (46–60) |
| NPV | 78 (75–81) | 84 (80–87) | 75 (73–78) |
| Accuracy | 67 (63–71) | 70 (66–74) | 70 (65–73) |
| AUC | 0.66 (0.62–0.70) | 0.76 (0.72–0.79) | 0.66 (0.62–0.70) |
AUC, area under the receiver operating characteristic curve; CI, confidence interval; MRI, magnetic resonance imaging; NPV, negative predictive value; PET, positron emission tomography; PPV, positive predictive value; and SPECT, single-photon emission computed tomography.