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. 2022 Jul 7;609(7925):101–108. doi: 10.1038/s41586-022-05049-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Timeline and normalized epidemiological curves for VOC detection in both wastewater and clinical sequences from San Diego County (includes wastewater samples collected from Point Loma wastewater treatment plant, UCSD, as well as public schools in the San Diego districts) for the three major VOCs in circulation during the sampling period (n = 475 wastewater, n = 22,504 clinical). Both Alpha and Delta variants are detected first in wastewater before clinical samples. Markers for clinical detections correspond to the ceiling of the daily detection count divided by 30 (for example, 1–30 samples = one marker, 31–60 = two markers), whereas wastewater markers correspond to a single detection. b, Timeline and epidemiological curves for VOC detection in the campus samples (n = 364 wastewater, n = 333 clinical). Markers correspond to a single detection event for both clinical and wastewater surveillance. All wastewater detections correspond to an estimated VOC prevalence of at least 10%.