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. 2022 Jul 7;609(7925):101–108. doi: 10.1038/s41586-022-05049-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–c, Maximum likelihood phylogenetic trees for each of the dominant VOCs (Epsilon (a), Alpha (b) and Delta (c)) using high-quality samples obtained at UCSD, as well as a representative set of sequences from the entire United States. Wastewater sequences from the same sampler that differ by one or fewer SNPs are denoted with a red asterisk. For all sequences, consensus bases were called at sites with more than 50% nucleotide frequency. Location information is provided for select outbreaks. d, Pairwise comparison of collection date for matching and near-matching wastewater and nasal swab samples obtained at UCSD. Positive values indicate earlier collection in nasal swabs and negative values indicate earlier detection in wastewater.