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. 2022 Aug 24;609(7925):191–196. doi: 10.1038/s41586-022-05114-0

Fig. 2. R-loop propagation drives DNA repositioning within Cas9.

Fig. 2

a, Zoomed-in views of the conformational transitions in the PAM-distal DNA duplex and Cas9 REC2 and REC3 domains in the 6-, 8- and 10-nt match complex. b, Zoomed-in view of the R-loop in the 6-nt match complex. c, Zoomed-in view of the R-loop in the 8-nt match complex. d, Zoomed-in view of the R-loop in the 10-nt match complex. e, Zoomed-in view of the interaction between the REC2 domain DDD helix and the REC3 RRR helix.