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. 2021 Dec 29;32(17):3611–3632. doi: 10.1093/cercor/bhab437

Figure 6.

Figure 6

Expression of some upper-layer neuronal genes is reduced after Bcl11a and Bcl11b depletion. (A–B′′′) In situ hybridization results show severely reduced expression of the pan-neuronal genes Cnr1 (A–A′′′) and Plk2 (B–B′′′) in the cortices of Bcl11a/b-DCKO mice at E15. (C–E′′′) Expression of layer IV projection neurons gene Rorb is missing, whereas Satb2 and Cux1 show reduced expression in the Bcl11a/b-DCKO mice at P0. (F–J) The FPKM values of the genes based on RNA-seq data at the ages corresponding to the in situ experiments (Student's t-test, N.S., not significant, *P < 0.05, ***P < 0.001, n = 3, mean ± SEM). Scale bars: 200 μm in B′′′ for A–B′′′; 300 μm in E′′′ for C–E′′′.