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. 2021 Dec 29;32(17):3611–3632. doi: 10.1093/cercor/bhab437

Figure 7.

Figure 7

Most of the deep-layer projection neuron marker genes are not expressed in the Bcl11a/b-DCKO cortices. (A–D′′′) In situ hybridization shows that expression of the corticothalamic neuron and subplate genes Tle4, Ppp1r1b, Npy, and Sox5 is almost absent in Bcl11a/b-DCKO cortices at P0. (E–F′′′) Some of the specific projection neuron genes confined in layer V, such as Etv1 and Foxp1, show reduced expression in the Bcl11a/b-DCKO cortices. (G–L) The FPKM values of the genes based on RNA-seq data at P0 (Student's t-test, N.S., not significant, **P < 0.01, ***P < 0.001, n = 3, mean ± SEM). Scale bars: 300 μm in F′′′ for A–F′′′.