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. 2021 Dec 29;32(17):3611–3632. doi: 10.1093/cercor/bhab437

Figure 8.

Figure 8

Defects of deep-layer projection neuron axonal projections in Bcl11a/b-DCKO at P0. (A–D′′) Sagittal sections show tdTomato staining in control (Emx1-cre; IS) brains (A–A′′), Bcl11a-CKO; IS brains (B–B″), Bcl11b-CKO; IS brains (C–C″), and Bcl11a/b-DCKO; IS brains (D–D″). (E, F, E′, F′) tdTomato+ axons extend through midbrain, pons, and medulla towards spinal cord in the control brains (E and F), whereas these axons are absent in both Bcl11a/b-DCKO (E′ and F′) and Bcl11b-CKO mice (C–C″). (G, G′) tdTomato+ axons are present in the internal capsule of control mice (G) but rare in Bcl11a/b-DCKO brains (G′). (H, H′) tdTomato+ corticothalamic axons are present in the control brains but absent in the thalamus of Bcl11a/b-DCKO brains. i.c., internal capsule; Th., thalamus. Scale bars: 600 μm in D″ for A–D″; 300 μm in F′ for E–F and E′–F′; 360 μm in H′ for G–H and G′–H′.