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. 2022 Mar 10;29(9):1689–1704. doi: 10.1038/s41418-022-00956-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A Calcified teeth obtained after kidney capsule transplantation for 4 weeks. Three-dimensional (3D) reconstruction images from micro-computed tomography of calcified teeth in the (a) mock-group and (d) USP49-depletion group. H&E staining images from the (b, c) mock-group and (e, f) USP49-depletion group. Scale bar: 100 µm. (a (a, b)) In mock-group, the tooth is well calcified and surrounded by bone. (c) Pulp, odontoblasts, dentin, and ameloblasts were observed in the mock group. (a (d, e)) In the USP49-depletion group, the tooth is not fully calcified and not surrounded by bone. (f) Tooth showed defects in the pulp, dentin formation with few odontoblasts, and enamel formation with few ameloblasts. Fifteen biological replicates per group (n = 15) (H&E staining was performed from six biological replicates with randomly selected sections per group). B Amelogenin and DSPP expression levels in the (a and a’; b and b’) mock group and (c and c’, d and d’) USP49-depletion group. Scale bar = 100 µm. a’, b’, c’, and d’ are higher magnification images of a, b, c, and d, respectively. Ab, ameloblast; ES, enamel space; D, dentin; Ob, odontoblast; P, pulp; dotted line, dentinoenamel junction; arrows, positive cells in ameloblasts; arrow heads, positive cells in odontoblasts. The microscopic images from six biological replicates with randomly selected sections per group.