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. 2022 Feb 25;29(9):1730–1743. doi: 10.1038/s41418-022-00960-x

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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2022, corrected publication 2022Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 6 — A A schematic diagram shows the animal experimental design for the crossing of Hi-Myc mice and OTUD6A null mice. B Depletion of Otud6a reduced the prostatic tumorigenesis of Hi-Myc PrCa mice. The prostate tumors/tissues were collected and weighed at 7-month of age. N = 7, 7, 5, and 6 for Otud6a^+/y, Otud6a^−/y, Hi-Myc;Otud6a^+/y and Hi-Myc;Otud6a^−/y group, respectively. ***p < 0.001. One-way ANOVA. C Representative images for the prostate tissue or tumor in Otud6a^+/y, Otud6a^−/y, Hi-Myc;Otud6a^+/y and Hi-Myc;Otud6a^−/y mice. D Depletion of Otud6a reduced the tumor weight in the different lobes of prostate in Hi-Myc mice. The DLP (dorsolateral prostate), VP (ventral prostate) and AP (anterior prostate) lobes of prostate tissue were collected and weighed for each mice at 7-month of age. N = 5 and 6 for Hi-Myc;Otud6a^+/y and Hi-Myc;Otud6a^−/y group, respectively. *p < 0.05, **p < 0.001. One-way ANOVA. E Representative images for the different lobes of prostate tumor in Hi-Myc;Otud6a^+/y and Hi-Myc;Otud6a^−/y mice. F Representative H&E staining images for the different lobes of prostate tumor in Hi-Myc;Otud6a^+/y and Hi-Myc;Otud6a^−/y mice at 7-month and 12-month of age. G Representative IHC staining images of c-Myc for the DLP lobe of prostate tumor in Hi-Myc;Otud6a^+/y and Hi-Myc;Otud6a^−/y mice.