Table 2.
HCC incidence overall and in key subgroups defined based on etiology and race/ethnicity.
| Frequency of patients | Frequency of patients with HCC | Person-years (PY) follow up | HCC Incidence per 100 PY | 95% Confidence Interval | |
|---|---|---|---|---|---|
| Overall | 2733 | 135 | 7418 | 1.82 | 1.51–2.13 |
| Etiology 1 | |||||
| Active hepatitis C virus (HCV)1 | 521 | 55 | 1636 | 3.36 | 2.47–4.25 |
| Cured HCV | 638 | 33 | 1927 | 1.71 | 1.13–2.30 |
| Alcohol related liver disease | 439 | 15 | 1133 | 1.32 | 0.65–1.99 |
| Nonalcoholic fatty liver disease | 822 | 24 | 1940 | 1.24 | 0.74–1.73 |
| Hepatitis B virus infection2 | 67 | 4 | 209 | 1.91 | 0.04–3.78 |
| Autoimmune hepatitis | 117 | 4 | 305 | 1.31 | 0.03–2.60 |
| Primary biliary cirrhosis | 75 | 0 | 176 | 0.00 | 0.00–0.00 |
| Primary sclerosing cholangitis | 22 | 0 | 56 | 0.00 | 0.00–0.00 |
| Other etiologies2 | 81 | 2 | 179 | 1.12 | 0.00–2.68 |
| Missing | 10 | 1 | 45 | 2.24 | 0.00–6.64 |
| Race/ethnicity | |||||
| Non-Hispanic White | 1373 | 72 | 3711 | 1.94 | 1.49–2.38 |
| Hispanics | 748 | 31 | 1879 | 1.65 | 1.07–2.23 |
| Non-Hispanic Black | 533 | 28 | 1618 | 1.73 | 1.09–2.38 |
1
HCV status was defined based on data at the time of cohort enrollment.
2
Only, 32 patients had HBV infection without other risk factors, with an annual HCC incidence rate of 1.13% (95% CI, 0.00, 3.35%).
See footnote for Table 1.