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. 2022 Aug 18;13:969783. doi: 10.3389/fendo.2022.969783

Table 3.

Association between AIP and new-onset NAFLD according to sex.

Model 1 Model 2 Model 3
HR (95%CI) P value
Sex= male
AIP quartiles
Q1 Ref. Ref. Ref.
Q2 2.87 (2.11, 3.90) P<0.001 2.26 (1.66, 3.08) P<0.001 2.36 (1.66, 3.37) P<0.001
Q3 4.92 (3.69, 6.57) P<0.001 3.13 (2.34, 4.18) P<0.001 2.97 (2.12, 4.16) P<0.001
Q4 12.38 (9.41, 16.30) P<0.001 5.89 (4.45, 7.78) P<0.001 5.07 (3.64, 7.05) P<0.001
P for trend (1 Q increment) 2.23 (2.08, 2.39) P<0.001 1.73 (1.61, 1.85) P<0.001 1.60 (1.48, 1.73) P<0.001
Sex= female
AIP quartiles
Q1 Ref. Ref. Ref.
Q2 2.53 (1.89, 3.40) P<0.001 1.94 (1.44, 2.60) P<0.001 1.74 (1.28, 2.38) P<0.001
Q3 4.24 (3.21, 5.58) P<0.001 2.74 (2.08, 3.61) P<0.001 2.29 (1.70, 3.07) P<0.001
Q4 10.97 (8.45, 14.24) P<0.001 5.22 (4.01, 6.80) P<0.001 3.96 (2.98, 5.26) P<0.001
P for trend (1 Q increment) 2.20 (2.06, 2.34) P<0.001 1.71 (1.61, 1.83) P<0.001 1.57 (1.46, 1.68) P<0.001
P for interaction 0.905 0.912 0.604

Model 1 was not adjusted. Model 2 was adjusted for age and BMI. Model 3 was adjusted for age, BMI, SBP, DBP, ALP, GGT, ALT, AST, CR, UA.