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. 2022 Aug 12;4(32):697–705. doi: 10.46234/ccdcw2022.146

Table 3. Comparison of guidelines on returning SFs in clinical setting.

Category US Canada UK Australia Denmark Germany EU
Abbreviation: ACA=analytic validity, clinical significance, and actionability; SFs=secondary findings; All-or-none policy=patients could choose to receive all SFs or none of them; UK=the United Kingdom; US=the United States.
General attitude
Positive attitude
Negative attitude
Minimization of SFs
No Harm principle
For adults
ACA criteria
Partial ACA criteria
Informed consent
Right to know
Right not to know
All-or-none policy
For clinicians
Must-return regardless of preference
Obligation to disclose
No obligation to disclose
Right to search
No obligation to search
Case-by-case determination
Decision by physicians
For children
Specific guidelines for children
Policy for children same as for adults
For genomic data
Data protection
Confidentiality