Fig. 3.

Structural comparison of CTDs from alpha‐ and betacoronaviruses. (A) Alphacoronavirus SADS, HKU‐2 and HcoV‐229E CTD structures. The CTDs of SADS and HKU‐2 belong to the one‐layer CTD subtype while that of HcoV‐229E belongs to the two‐layer CTD subtype. The CTD core is shown in blue and RBM in red. PDB codes: SADS, 6M16; HKU‐2, 6M15; HcoV‐229E, 6U7H. (B) Betacoronavirus SARS‐CoV, SARS‐CoV‐2 and MERS‐CoV CTD structures. These three Betacoronavirus CTDs belong to the one‐layer CTD subtype. The CTD core is shown in blue and RBM in red. PDB codes: SARS‐CoV, 2AJF; SARS‐CoV‐2, 6M0J; MERS‐CoV, 4L7A. [Colour figure can be viewed at wileyonlinelibrary.com]