Fig. 4.

RBD efficient down‐to‐up conformational change and high‐affinity binding to ACE2 are both required for SARS‐CoV‐2 to gain high infectivity. (A) The structures of SARS‐CoV‐2 S glycoprotein and human ACE2 are shown in surface representation. PDB codes: SARS‐CoV‐2 S glycoprotein, 6VXX, 6VYB; human ACE2, 6M0J. (B) The percentage of close and open RBD conformations for SARS‐CoV‐2 A372T, wild‐type (WT) and D614G S glycoprotein. Open conformation is shown in blue and closed conformation in green. [Colour figure can be viewed at wileyonlinelibrary.com]