Table 3.
Hippo-YAP pathway and inflammation in atherosclerosis.
| Model | species | Methods | Outcomes | Inflammation outcomes | Ref. |
|---|---|---|---|---|---|
| Disturbed flow | Mouse | Endothelial-specific knockout of Yap/Taz | Retard progression of atherosclerosis | Decrease monocyte attachment and infiltration; Decrease expression of pro-inflammation cytokines | (54, 148–151) |
| Disturbed flow | Mouse | Endothelial-specific overexpression of Yap/Taz | Increase atherosclerotic plaque formation | Promote endothelial inflammation | (148) |
| High fat diet | Mouse | Endothelial-specific knockout of Jcad | Retard progression of atherosclerosis | (152) | |
| High fat diet | Mouse | Mutation the integrin binding site in phosphodiesterase 4D5 | Retard progression of atherosclerosis | Decrease monocyte attachment and infiltration; Decrease expression of pro-inflammation cytokines | (153) |
| High fat diet | Mouse | Endothelial-specific overexpression of Yap | Increase atherosclerotic plaque formation | Increase expression of pro-inflammation cytokines | (154) |
| Disturbed flow | Mouse | Endothelial-specific overexpression of c-Abl | Increase atherosclerotic plaque formation | Increase expression of pro-inflammation cytokines | (154) |
| Disturbed flow | Mouse | Endothelial-specific knockout of Bach1 | Retard progression of atherosclerosis | Decrease macrophage infiltration; Decrease expression of pro-inflammation cytokines | (155) |
| High fat diet | Mouse | Endothelial-specific knockout of Bach1 | Retard progression of atherosclerosis | Decrease macrophage infiltration; Decrease expression of pro-inflammation cytokines | (155) |
| High fat diet | Mouse | Endothelial-specific knockout of Jcad | Retard progression of atherosclerosis | Decrease macrophage infiltration; Decrease expression of pro-inflammation cytokines | (156) |
| High fat diet | Mouse | Macrophage-specific deletion of Yap | Retard progression of atherosclerosis | Decrease macrophage infiltration; Decrease expression of pro-inflammation cytokines | (157) |
| High fat diet | Mouse | Macrophage-specific overexpression of Yap | Aggravate progression of atherosclerosis | Increase macrophage infiltration; Increase expression of pro-inflammation cytokines | (157) |