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. 2022 Aug 23;40(8):111280. doi: 10.1016/j.celrep.2022.111280

Figure 5.

Figure 5

Recovery of deficient astrocyte signaling mitigates network hypersynchrony and behavior hyperactivity in early AD

(A and B) BOLD FC matrices (A) and graphs quantifying FC (Z scores ± SEMs) (B) between the anterior and posterior cingulate cortex (indicated in matrices by asterisk) upon modulation of astrocyte calcium activity in AppNL control and AppNL-F mice expressing mCherry or DREADDs (GFAP promoter) (N = 8/group). ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001, 1-way ANOVA with Sidak correction.

(C) Seizure susceptibility (seizure score ± SEM) to a subconvulsive dose of PTZ (30 mg/kg) for AppNL control (N = 15/group) and AppNL-F mice (N = 16/group) expressing mCherry or DREADDs. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗∗p < 0.0001, Kruskal-Wallis test with Dunn’s correction.

(D and E) Behavior analyses of day/night activity of AppNL control and AppNL-F mice expressing mCherry (AppNL control mCherry N = 15, AppNL-F mCherry N = 16) or DREADDs (AppNL control DREADDs N = 18, AppNL-F DREADDs N = 19) over 24 h (counts of photobeam crosses ± SEMs). ∗∗∗∗p < 0.0001, 1-way ANOVA with Sidak correction.