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. 2022 Aug 18;13:957865. doi: 10.3389/fimmu.2022.957865

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Copyright © 2022 Sun, Li, Wang, Zhang, Li, Du, Yin, Xiao and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein–protein interaction (PPI) network construction and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of differentially expressed genes (DEGs) between HEIH/YBX3 high-expression and low-expression groups in COAD. (A) Volcano map of DEGs of HEIH expression in COAD (red: upregulation; blue: downregulation). (B) GO and KEGG pathway enrichment analyses of DEGs of HEIH in the form of a chordal graph. (C, a) Hub genes of PPI network (ranking first) and MCODE2 components identified in the gene lists. (C, b) Enrichment analysis of the hub gene network. (D, a) Hub genes of PPI network (ranking second) and MCODE2 components identified in the gene lists. (D, b) Enrichment analysis of the hub gene network. (E, a) Hub genes of PPI network (ranking third) and MCODE2 components identified in the gene lists. (E, b) Enrichment analysis of the hub gene network. (F) Volcano map of DEGs of YBX3 expression in COAD (purple: upregulation; blue: downregulation). (G) GO and KEGG pathway enrichment analyses of DEGs of YBX3 in the form of a chordal graph. (H, a) Hub genes of PPI network (ranking first) and MCODE2 components identified in the gene lists. (H, b) Enrichment analysis of the hub gene network. (I, a) Hub genes of PPI network (ranking second) and MCODE2 components identified in the gene lists. (I, b) Enrichment analysis of the hub gene network. (J, a) Hub genes of PPI network (ranking third) and MCODE2 components identified in the gene lists. (J, b) enrichment analysis of the hub gene network.