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. 2022 Aug 18;13:957865. doi: 10.3389/fimmu.2022.957865

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Copyright © 2022 Sun, Li, Wang, Zhang, Li, Du, Yin, Xiao and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of YBX3 expression on immune/immunosuppressive cells across The Cancer Genome Atlas (TCGA) cancers and on the biomarker value of ICB sub-cohorts and YBX3 expression profile in different immune cells. (A) Correlations between YBX3 expression and infiltration of six immune cell types across all cancer types in TCGA cohorts. (B) Correlations of YBX3 expression with three immunosuppressive cell types in various TCGA cancer types. (C) Biomarker relevance of MXD3 compared to standardized cancer immune evasion biomarkers in immune checkpoint blockade sub-cohorts. (D, E) Presenting YBX3 and HEIH expression profile in different immune cells using scRNA-seq data from GEO database.