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. 2022 Jun 23;28(17):3742–3751. doi: 10.1158/1078-0432.CCR-22-0203

Figure 1.

Figure 1. Homology-directed repair (HDR) assay evaluation of clinically observed BRCA2 DNA-binding domain (DBD) missense variants. HDR scores with 95% confidence intervals (CI) are presented on a 1 to 5 scale based on HDR activity of wild-type BRCA2 (HDR score = 5) and the p.Asp2723His non-functional pathogenic variant (HDR score = 1). HDR thresholds for functional (>2.50) and non-functional (<1.49) are indicated by horizontal dotted lines. Variants are ordered on the basis of amino acid position (x-axis).

Homology-directed repair (HDR) assay evaluation of clinically observed BRCA2 DNA-binding domain (DBD) missense variants. HDR scores with 95% confidence intervals (CI) are presented on a 1 to 5 scale based on HDR activity of wild-type BRCA2 (HDR score = 5) and the p.Asp2723His non-functional pathogenic variant (HDR score = 1). HDR thresholds for functional (>2.50) and non-functional (<1.49) are indicated by horizontal dotted lines. Variants are ordered on the basis of amino acid position (x-axis).