TABLE 2.

Summary of HIGS applications for control of bacterial pathogens.

Pathogen	Host	RNA type	Target gene(s)	Main effect(s)	References
A. tumefaciens	Arabidopsis Tobaco	siRNA	iaaM ags	Inhibited infection	Dunoyer et al., 2006
A. tumefaciens	Rice	hpRNA	OsPDS OsSLR1	Triggered degradation of target transcripts in the adjacent tissues	Andrieu et al., 2012
A. tumefaciens	Walnut	dsRNA	iaaM ipt	Decreased crown gall formation	Walawage et al., 2013
A. tumefaciens	Plum Apricot	hpRNA	iaaM ipt	Induces resistance to crown gall disease in plum but not in apricot	Alburquerque et al., 2017
Pectobacterium carotovorum (Soft rot)	Potato	miRNA	aiiA	Induced resistance to the early stage of bacterial pathogenesis	Mahmoudi and Soleimani, 2019

hpRNA, hairpin RNA; dsRNA-Double-stranded RNA; siRNA, Small interfering RNA; miRNA, micro RNA.