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. 2022 Aug 18;15:937468. doi: 10.3389/fnmol.2022.937468

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Copyright © 2022 Chen, Xie, Li, Fan, Xing, Mao, Xing, Wang, Yang, Wang and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paw withdrawal threshold (A) and paw withdrawal latency (B) in rats. Rats 1–8 in the Sham group and 1–8 in the SDR group. The PWT and PWL of rats decreased significantly after 6 days of SD, and the PWL recovered after 2 days of RS compared to 6 days of SD, and both PWT and PWL returned to baseline levels after 4 days of RS. ****P < 0.0001 compared to the sham group. ^####P < 0.0001 compared with baseline and RS4d in the SDR group.