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. 2022 Aug 18;9:896348. doi: 10.3389/fnut.2022.896348

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Copyright © 2022 Huda, Salvador, Barrington, Gacasan, D'Souza, Deus Ramirez, Threadgill and Bennett.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diet-gene interaction on gut microbiota. Shannon diversity index (A) and Faith's PD (B) α-diversity by diet and strain. Boxes without a common letter are significantly (p < 0.05) different from others. Boxes with common letters represent no significant difference. 2-way ANOVA with Tukey's post hoc analysis was performed to determine the statistical differences. (C) Weighted UniFrac β-diversity PCoA plot. The color of the point represents diet. The ellipse on the principal coordinate analysis plot indicates 95% CI of the clusters by groups. Inset box is the results of ADONIS test on diet, strain, and their interaction. ADONIS analyses were adjusted for sex as a covariate. (D) Mean relative abundance of top 20 genera in A/J, C57BL/6J, FVB/NJ, and NOD/ShiLtJ mice treated with control mouse diet, WD, JD, KD, or MeD.