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. 2022 Jul 11;41(17):e108780. doi: 10.15252/embj.2021108780

Figure 6. Biasing of bipotent progenitors through the “hub” state towards sympathoadrenal progenitors and immature Schwann cells.

Figure 6

  • A
    Subset tree selection of the trajectory from trunk NCCs to immature Schwann cells versus sympathoadrenal progenitors. An abstract dendrogram is displayed on the right.
  • B
    Mean expression of early and late gene modules for each branch and overlayed tree on the early gene modules.
  • C
    Heatmap of early and late genes for each branch, with mean expression shown on the dendrogram representations.
  • D
    Inter‐/intra‐correlation analysis of early gene modules of both branches, on nonintersecting windows of cells over the trajectory.
  • E
    Inter‐ and intra‐module correlation performed on a sliding window of cells (over 100 probabilistic mappings of the trajectory) along the pseudotime axis. iSCs, immature Schwann cells; SA progenitors, sympathoadrenal progenitors.