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. 2022 Aug 18;13:963955. doi: 10.3389/fimmu.2022.963955

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Copyright © 2022 Zhu, Wang, Liu, Li, Yu, Li, Deng and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The key process of neutrophil pyroptosis in sepsis. In the classical pathway, pathogens, bacteria and other signals can recognize the intracellular NLR family and activate casepase-1 by forming inflammasome. Capsase-1 can cleave pro-IL-1β to IL-1β inducing inflammation. Whereas in the non-classical pathway, the participation of inflammasome is not necessary for the activation of caspase-4/5/11. Capsase-4/5/11 can cleave GSDMD to N-GSDMD and promote NET release. GSDMD can also be cleaved by NE to promote NETs release. Some possible targets for reducing NETs release during sepsis are pointed out.