Table 2.

Group results of fMRI data.

			MNI coordinates			T	Cluster	Cluster
Contrast	Region	Side	x	y	z	Value	P value	Size
MS
Recovery > pre	Middle temporal gyrus	L	−62	−20	−6	5.86	< 0.001	500
	Inferior frontal gyrus (pars triangularis)	L	−34	26	20	5.76	< 0.001	341
	Superior frontal gyrus	R	22	38	52	5.26	0.02	146
	Middle cingulum gyrus	L	−2	−10	44	4.97	< 0.001	297
	Paracentral lobule	R	2	–32	70	4.95	< 0.001	420
	Precentral gyrus	R	32	−26	74	4.91	0.038	126
	Middle frontal gyrus (pars orbital)	L	−34	46	−6	4.91	0.001	239
	Hippocampus	L	−12	−36	6	4.9	0.008	175
	Inferior frontal gyrus (pars orbitalis)	L	−40	34	−6	4.82	0.015	155
	Cerbellum (Crus2)	R	34	−78	−40	4.51	0.001	244
	Precuneus	L	−2	−68	46	4.4	< 0.001	341
	Medial superior frontal gyrus	L	0	56	2	4.34	0.006	187
Recovery > pre FSMCmotor	PMd	L	−34	2	66	4.11	0.03SVC	32
		L	−40	2	62	3.85
		L	−48	10	54	3.87	0.073SVC*	16
		L	−26	10	68	3.72	0.069SVC*	17
HC
Recovery > pre	Primary motor cortex	R	42	−20	56	5.4	0.011	175
	Middle temporal gyrus	R	62	−4	−14	5.46	0.056*	119
	Pre- & postcentral gyrus	R	62	−6	34	4.62	0.082*	107
Recovery > pre FSMCmotor	–
MS > HC
Recovery > pre	Middle frontal gyrus	R	32	38	16	5.26	0.034	149
	Middle frontal gyrus	L	−24	40	20	4.94	0.051*	134
	Putamen	L	−28	0	−12	4.9	0.012	189
	Putamen	R	22	10	−2	3.92	0.061*	127
Recovery > pre FSMCmotor	–

Table 2. The table lists clusters in the brain showing a change in task related activation after acute induction of motor fatigue compared to pre-fatigue activation at baseline (recovery > pre-fatigue) or a change in the relationship between the individual FSMCmotor scores and task related activation as triggered by acute induction of motor fatigue (recovery > pre FSMC_motor). The cluster-forming threshold was set to an uncorrected p-value ≤ 0.001. Findings were considered significant at family-wise error (FWE) corrected p < 0.05 at the cluster level.

* Trend findings showing a p-value ≤ 0.1 (FWE, cluster level) and a cluster extent of ≥ 10 voxels.

SVC: Significant results with small volume correction, p < 0.05 (FWE, cluster-level). Small volume corrected was performed with whole PMd L as mask (HMAT 10).

SVC*: Trend findings showing a p-value < 0.1 (FWE, cluster-level) and a cluster extent of ≥ 10 voxels.

Within-group analyses of MS patients were corrected for age and JTHF. Within-group analyses of healthy controls were corrected for age and JTHF. Between MS patients and healthy controls group analysis: corrected for age, JTHF and duration. Cluster size = number of voxels.

Abbreviations: FSMC_MOTOR = Fatigue Scale for Motor and Cognitive Functions, motor subscale, HC = Healthy controls, MS = Multiple sclerosis, PMd = Dorsal premotor cortex, Pre = Pre-fatigue phase, R = Right hemisphere, t = T-value.